Design and Synthesis of Oligoamide‐Based Double α‐Helix Mimetics
Identifieur interne : 000009 ( Main/Exploration ); précédent : 000008; suivant : 000010Design and Synthesis of Oligoamide‐Based Double α‐Helix Mimetics
Auteurs : Oleg V. Kulikov [États-Unis] ; Sam Thompson ; Hai Xu [États-Unis] ; Christopher D. Incarvito [États-Unis] ; Richard T. W. Scott ; Ishu Saraogi [États-Unis] ; Laura Nevola [Espagne] ; Andrew D. Hamilton [États-Unis, Royaume-Uni]Source :
- European Journal of Organic Chemistry [ 1434-193X ] ; 2013-06.
English descriptors
Abstract
An extensive series of bis‐oligobenzamides and bis‐oligopyridylamides have been efficiently prepared and studied by X‐ray analysis and computational methods. A modular synthesis led to double α‐helix mimics bearing between two and ten branched side‐chains. The inter‐helix angle and distance can be tuned by varying the length and rigidity of the spacer, thereby reproducing the recognition domains of a range of super‐secondary structures.
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DOI: 10.1002/ejoc.201300363
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